GR 125743

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GR 125743 是一种新型 5-HT1B/1D 受体拮抗剂。GR-125743 是一种新型放射性标记化合物衍生物，对血清素人 (h5-HT1D) 和人 (h5-HT1B) 受体表现出选择性拮抗特性。该化合物的特点是能够标记克隆的 h5-HT1D 和 h5-HT1B 受体。

GR 125743 is a novel antagonist of 5-HT1B/1D receptor.GR-125743, a new radiolabelled derivative of a compound that exhibits selective antagonistic properties with respect to the serotonin human (h5-HT1D) and human (h5-HT1B) receptors.?The compound has been characterized for its ability to label the cloned h5-HT1D and h5-HT1B receptors.?

GR 125743 has a Kd of 0.61 nM for h5-HT1B.

GR 125743 (0.3 mg/kg; i.p.) produces significant decreases in extracellular 5-HT in the frontal cortex of the conscious guinea pig. Animal Model:Male Dunkin Hartley guinea-pigs (350-450 g)Dosage:0.3 mg/kg Administration:Intraperitoneal injection Result:Produced significant transient increases in extracellular 5-HT.

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Endocrinology/Hormones

5-HT Receptor

5-HT1B/1D

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148547-33-5

416.53

C25H28N4O2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (240.08 mM)

COc1ccc(NC(=O)c2ccc(c(C)c2)-c2ccncc2)cc1N1CCN(C)CC1

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(-20℃)

With Ice Pack

≥ 2 years